HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl bromoacetate → Acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 3,3-Difluoroindolin-2-one | HCID 5323821 | — |
| Product | Acetate | HCID 175 | — |
| Product | tert-Butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate | HCID 68754561 | — |
Reaction Steps
The title compound was prepared from 3,3-difluoroindolin-2-one using protocol K except using tert-butyl 2-bromoacetate to give crude tert-butyl difluoro-2-oxoindolin-1-yl)acetate as a yellow oil. LCMS method [1] showed an M+Na peak of 306.1 with a retention time of 2.502 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-309a71cb9c6d496084edf8434de06374 |
| Source note | uspto-grants-2013_05 |