HuagongsheHuagongshe Chemistry Print Report · For research reference only
HOAt → N-(4-Bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-(trifluoromethyl)quinolin-7-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 2-(2-(Trifluoromethyl)quinolin-7-yl)acetic acid | HCID 68754783 | — |
| Reactant | HCID 178509325 | HCID 178509325 | — |
| Product | N-(4-Bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-(trifluoromethyl)quinolin-7-yl)acetamide | HCID 178520190 | — |
Reaction Steps
The title compound was synthesized via protocol B from 2-(2-(trifluoromethyl)quinolin-7-yl)acetic acid and 4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine, using HOAt instead of HOBt. HPLC purification afforded the product as a white solid. HPLC method [7], retention time 8.68 min; MS (ESI) 484.2 (MH+, 81Br); 1H NMR (300 MHz, CD3OD) δ 8.76 (d, J=9.5 Hz, 1H), 8.25 (d, J=9.0 Hz, 1H), 7.96 (dd, J=8.7, 7.3 Hz, 1H), 7.92-7.81 (m, 1H), 7.11-6.97 (m, 1H), 4.45 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e873cd46d85a4415acd73bbf6b2f525f |
| Source note | uspto-grants-2013_05 |