2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetic acid → HCID 178521251, compound

HRID 2098082Notes

Reaction equation

HRID 2098082 reaction equation
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=O.[Cl:16][C:17]1[C:18]([C:23]2[N:27]=[CH:26][NH:25][N:24]=2)=[C:19]([NH2:22])[S:20][CH:21]=1>>[Cl:16][C:17]1[C:18]([C:23]2[N:27]=[CH:26][NH:25][N:24]=2)=[C:19]([NH:22][C:13](=[O:15])[CH2:12][N:3]2[C:4]3[C:9](=[N:8][CH:7]=[CH:6][CH:5]=3)[CH:10]=[CH:11][C:2]2=[O:1])[S:20][CH:21]=1

Participants

3

Reactant 2

HCID 687824352-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetic acidHCID 178509326HCID 178509326, compound

Product 1

HCID 178521251HCID 178521251, compound

Procedure

The title compound was prepared from 2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetic acid (0.13 g, 0.62 mmol) and 4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-amine (0.22 g, 1.12 mmol) according to protocol A and purified by prep HPLC. Retention time (min)=1.010, method [4], MS (ESI) 389.0 (M+H).

Workup

  1. custompurified by prep HPLC

Sources & evidence

ORD record
ord-115e4f2ce31442658cff90a97a9f40ee
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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