HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 2-(8-Fluoroisoquinolin-5-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Tert-butyl 2-(8-fluoroisoquinolin-5-yl)acetate | HCID 68758654 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(8-Fluoroisoquinolin-5-yl)acetic acid | HCID 68758883 | — |
Reaction Steps
To a solution of the above ester (200 mg) in DCM (2 mL) was added formic acid (3 mL). The reaction was sealed with a Teflon cap and heater to 50° C. for 16 h. The solvent was removed and the crude product was used without further purification. LCMS showed an m/z of 206.1 with a retention time of 0.437 min, method [1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-2e70f9b539dc475cbab9e4dc840838bb |
| Source note | uspto-grants-2013_05 |