(6-Methylimidazo[2,1-b][1,3]thiazol-3-yl)acetic acid → HCID 68785158, compound

HRID 2098103Notes

Reaction equation

HRID 2098103 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([CH:9]=1)[C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][S:5]2.[Br:14][C:15]1[C:16]([C:21]2[NH:25][N:24]=[CH:23][N:22]=2)=[C:17]([NH2:20])[S:18][CH:19]=1>>[Br:14][C:15]1[C:16]([C:21]2[NH:25][N:24]=[CH:23][N:22]=2)=[C:17]([NH:20][C:11](=[O:13])[CH2:10][C:7]2[N:8]3[CH:9]=[C:2]([CH3:1])[N:3]=[C:4]3[S:5][CH:6]=2)[S:18][CH:19]=1

Participants

3

Reactant 2

HCID 12461970(6-Methylimidazo[2,1-b][1,3]thiazol-3-yl)acetic acidHCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine

Product 1

HCID 68785158HCID 68785158, compound

Procedure

The title compound was synthesized from 2-(6-methylimidazo[2,1-b]thiazol-3-yl)acetic acid and 4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-amine according to protocol A. Retention time (min)=8.520, method [6], MS (ESI) 423.0 (M+H); 1F1 NMR (300 MHz, CD3Cl) δ 8.12 (s, 1H), 7.35 (s, 1H), 7.22 (s, 1H), 7.0 (s, 1H), 4.15 (s, 2H), 2.50 (s, 3H).

Sources & evidence

ORD record
ord-f4983b48afb747e3b597c4b6de8af94e
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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