HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2098116Generated: November 1, 2026
Hydrochloric Acid → 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid
https://huagongshe.com/reaction/2098116
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | methyl 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetate | HCID 68782506 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid | HCID 68786843 | — |
Reaction Steps
Aqueous 1N HCl (2 mL) was added to a solution of methyl 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetate (1.24 g, 5.67 mmol) in acetic acid (5 mL) and the resulting mixture was heated to 60° C. for 4 h. The solution was concentrated under vacuum to give 2-(2-Oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid. Retention time (min)=0.275, method [1], MS (ESI) 207.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450363B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-fcda53afffd54bd39bc860d9723593e2 |
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| Source note | uspto-grants-2013_05 |
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