2-(Isoquinolin-5-YL)acetic acid → HCID 46868994, compound

HRID 2098120Notes

Reaction equation

HRID 2098120 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[CH3:15][O:16][C:17]1[S:18][CH:19]=[C:20]([C:22]2[S:23][CH:24]=[CH:25][C:26]=2[NH2:27])[N:21]=1>>[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([NH:27][C:26]3[CH:25]=[CH:24][S:23][C:22]=3[C:20]3[N:21]=[C:17]([O:16][CH3:15])[S:18][CH:19]=3)=[O:14])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68755864HCID 68755864, compound

Product 1

HCID 46868994HCID 46868994, compound

Procedure

The title compound was prepared from 2-(isoquinolin-5-yl)acetic acid (72 mg, 0.36 mmol) and 2-(2-methoxythiazol-4-yl)thiophen-3-amine (78 mg, 0.36 mmol) according to protocol A. Retention time (min)=3.237, method [7], MS (ESI) 382.0 (M+H); 1H NMR (300 MHz, CDCl3) δ 10.99 (s, 1H), 9.69 (s, 1H), 8.60 (d, J=6.5 Hz, 1H), 8.39 (d, J=6.5 Hz, 1H), 8.23 (d, J=8.4 Hz, 1H), 8.06 (d, J=7.3 Hz, 1H), 7.96 (d, J=5.5 Hz, 1H), 7.89 (dd, J=8.4, 7.3, 1H), 7.15 (d, J=5.5, 1H), 6.70 (s, 1H), 4.26 (s, 2H), 4.17 (s, 3H).

Sources & evidence

ORD record
ord-16f44485af3e41498ef613781633c2eb
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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