2-(Isoquinolin-5-YL)acetic acid → HCID 46869070, compound

HRID 2098122Notes

Reaction equation

HRID 2098122 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[Cl:15][C:16]1[S:17][CH:18]=[C:19]([C:21]2[S:22][CH:23]=[CH:24][C:25]=2[NH2:26])[N:20]=1>>[Cl:15][C:16]1[S:17][CH:18]=[C:19]([C:21]2[S:22][CH:23]=[CH:24][C:25]=2[NH:26][C:12](=[O:14])[CH2:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)[N:20]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68755464HCID 68755464, compound

Product 1

HCID 46869070HCID 46869070, compound

Procedure

The title compound was prepared from 2-(isoquinolin-5-yl)acetic acid (218 mg, 1.11 mmol) and 2-(2-chlorothiazol-4-yl)thiophen-3-amine (241 mg, 1.11 mmol) according to protocol A. Retention time (min)=3.049, method [7], MS (ESI) 385.89 (M+H); 1H NMR (300 MHz, CD3OD) δ 9.54 (s, 1H), 8.56 (d, J=6.4 Hz, 1H), 8.39 (d, J=6.4 Hz, 1H), 8.31 (d, J=8.1 Hz, 1H), 8.16 (d, J=6.8 Hz, 1H), 7.94 (dd, J=8.1, 7.2 Hz, 1H), 7.73 (d, J=5.5 Hz, 1H), 7.45 (s, 1H), 7.37 (d, J=5.5 Hz, 1H), 4.39 (s, 2H).

Sources & evidence

ORD record
ord-af47e029cc6847a9bd3aabaef1f2b77e
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

Loading…