2-(Isoquinolin-5-YL)acetic acid → HCID 46868998, compound

HRID 2098124Notes

Reaction equation

HRID 2098124 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[S:7][CH:8]=[CH:9][C:10]=1[NH2:11].[CH:12]1[C:21]2[C:16](=[C:17]([CH2:22][C:23](O)=[O:24])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1>>[CH:12]1[C:21]2[C:16](=[C:17]([CH2:22][C:23]([NH:11][C:10]3[CH:9]=[CH:8][S:7][C:6]=3[C:2]3[S:1][CH:5]=[CH:4][N:3]=3)=[O:24])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68754843HCID 68754843, compound

Product 1

HCID 46868998HCID 46868998, compound

Procedure

The title compound was prepared from 2-(thiazol-2-yl)thiophen-3-amine and 2-(isoquinolin-5-yl)acetic acid according to protocol A. Preparative HPLC gave 2-(isoquinolin-5-yl)-N-(2-(thiazol-2-yl)thiophen-3-yl)acetamide. Method[7], MS (ESI) 352.1 [M+H], Retention time=2.59 min; 1H-NMR (300 MHz, CDCl3) δ 11.32 (s, 1H), 8.26 (d, J=8.2 Hz, 1H), 8.10-8.09 (m, 1H), 8.07 (s, 1H), 7.94 (t, J=7.7 Hz, 1H), 7.35 (d, J=3.3 Hz, 1H), 7.31-7.24 (m, 4H), 7.10 (d, J=3.3 Hz, 1H), 4.33 (s, 2H).

Sources & evidence

ORD record
ord-a6ab34a50ad540688d56eea80d320c3f
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

Loading…