4-Methoxyphenylacetic Acid → HCID 46869000, compound

HRID 2098148Notes

Reaction equation

HRID 2098148 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.[O:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]1[S:19][CH:20]=[CH:21][C:22]=1[NH2:23]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([NH:23][C:22]2[CH:21]=[CH:20][S:19][C:18]=2[C:14]2[O:13][CH:17]=[CH:16][N:15]=2)=[O:12])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68754240HCID 68754240, compound

Product 1

HCID 46869000HCID 46869000, compound

Procedure

2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-yl)acetamide was prepared from 2-(4-methoxyphenyl)acetic acid 64 mg, 0.385 mmol) and 2-(oxazol-2-yl)thiophen-3-amine (64 mg, 0.385 mmol) according to protocol A. Retention time (min)=6.845, method [7], MS (ESI) 315.1 (M+H); 1H NMR (300 MHz, CDCl3) δ 10.59 (s, 1H), 8.17 (d, J=5.2 Hz, 1H), 7.52 (s, 1H), 7.28-7.37 (m, 3H), 6.94-6.99 (m, 3H), 3.85 (s, 3H), 3.66 (s, 2H).

Sources & evidence

ORD record
ord-2cd174727ce94f3a84acc6f666fa9b60
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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