HCID 68754462, compound → HCID 56672175, compound

HRID 2098151Notes

Reaction equation

HRID 2098151 reaction equation
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=O.[Br:16][C:17]1[C:18]([C:23]2[O:24][CH:25]=[CH:26][N:27]=2)=[C:19]([NH2:22])[S:20][CH:21]=1>>[Br:16][C:17]1[C:18]([C:23]2[O:24][CH:25]=[CH:26][N:27]=2)=[C:19]([NH:22][C:13](=[O:15])[CH2:12][N:3]2[C:4]3[C:9](=[N:8][CH:7]=[CH:6][CH:5]=3)[CH2:10][CH2:11][C:2]2=[O:1])[S:20][CH:21]=1

Participants

3

Reactant 2

HCID 68754462HCID 68754462, compoundHCID 68782483HCID 68782483, compound

Product 1

HCID 56672175HCID 56672175, compound

Procedure

The title compound was prepared from 2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetic acid (85 mg, 0.416 mmol) and 4-bromo-3-(oxazol-2-yl)thiophen-2-amine (51 mg, 0.208) mmol) according to protocol A. Retention time (min)=3.245, method [7], MS (ESI) 433.0 (M+H); 1H NMR (300 MHz, CDCl3) δ 8.39 (dd, J=5.1, 1.0 Hz, 1H), 7.72 (s, 1H), 7.55 (d, J=7.0 Hz, 1H), 7.45 (dd, J=8.4, 5.5 Hz, 1H), 7.17 (s, 1H), 6.94 (s, 1H), 4.93 (s, 2H), 3.51-3.46 (m, 2H), 3.05-3.00 (m, 2H).

Sources & evidence

ORD record
ord-d05a8427fb61449dbdc588765aab4a2b
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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