4-Methoxyphenylacetic Acid → HCID 46869151, compound

HRID 2098176Notes

Reaction equation

HRID 2098176 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH2:12])[CH:6]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](O)=[O:23])=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([NH:12][C:11]2[CH:10]=[CH:9][S:8][C:7]=2[N:5]2[CH:6]=[C:2]([CH3:1])[CH:3]=[N:4]2)=[O:23])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68784506HCID 68784506, compound

Product 1

HCID 46869151HCID 46869151, compound

Procedure

The title compound was prepared from 2-(4-methyl-1H-pyrazol-1-yl)thiophen-3-amine and 2-(4-methoxyphenyl)acetic acid using protocol B and purified by HPLC. Method [7] Retention time 6.16 min by HPLC (MH+ 328). 1H NMR (300 MHz, CDCl3) δ 9.93 (broad s, 1H), 7.97 (d, J=6.0 Hz, 1H), 7.38 (s, 1H), 7.19 (s, 1H), 7.27 (d, J=8.7 Hz, 2H), 6.96 (d, J=8.7 Hz, 2H), 6.90 (d, J=6.0 Hz, 1H), 3.87 (s, 3H), 3.70 (s, 2H), 2.11 (s, 3H).

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-97168612d4b2486d9ed39f64291c3b08
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

Loading…