2-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acid → HCID 68785461, compound

HRID 2098199Notes

Reaction equation

HRID 2098199 reaction equation
[CH3:1][C:2]1[N:3]([C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:4]=[C:5]([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH2:12])[N:6]=1.[O:32]=[C:33]1[CH2:42][CH2:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[N:34]1[CH2:43][C:44](O)=[O:45]>>[CH3:1][C:2]1[N:3]([C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:4]=[C:5]([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH:12][C:44](=[O:45])[CH2:43][N:34]2[C:35]3[C:40](=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:41][CH2:42][C:33]2=[O:32])[N:6]=1

Participants

3

Reactant 2

HCID 167842212-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acidHCID 68757154HCID 68757154, compound

Product 1

HCID 68785461HCID 68785461, compound

Procedure

The title compound was prepared from 2-(2-methyl-1-trityl-1H-imidazol-4-yl)thiophen-3-amine and 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid using protocol B (125 mg). Method [7] Retention time 7.33 min by HPLC (MH+ 609).

Sources & evidence

ORD record
ord-8f4196e18a4640ec8120ca073fac91bb
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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