HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitrothiophene → 4-Methyl-1-(3-nitrothiophen-2-yl)-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitrothiophene | HCID 220186 | — |
| Reactant | HCID 178418800 | HCID 178418800 | — |
| Product | 4-Methyl-1-(3-nitrothiophen-2-yl)-1H-imidazole | HCID 68785636 | 49% |
Reaction Steps
4-methyl-1(3-nitrothiophen-2-yl)-1H-imidazole was prepared from 2-chloro-3-nitrothiophene and 4-methyl-1H-imidazole according to the procedure described in Example 9.7.1., above. Purification by flash column chromatography (silica, 40:60 ethyl acetate/hexane) gave the nitro intermediate (1.26 g, 49%). 1H-NMR (CDCl3) δ 7.67 (s, 1H), 7.59 (d, J=6.1 Hz, 1H), 7.19 (d, J=6.1 Hz, 1H), 6.89 (s, 1H), 2.27 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450363B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-3dd654d798914d27a9b0a790aa372a18 |
| Source note | uspto-grants-2013_05 |