4-Methoxyphenylacetic Acid → 2-(4-Methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide

HRID 2098206Notes

Reaction equation

HRID 2098206 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]1[S:8][CH:9]=[CH:10][C:11]=1[NH2:12].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](O)=[O:23])=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([NH:12][C:11]2[CH:10]=[CH:9][S:8][C:7]=2[C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[O:23])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 687575962-(Pyrazin-2-yl)thiophen-3-amine

Product 1

HCID 529412862-(4-Methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide

Procedure

The title compound was prepared from 2-(pyrazin-2-yl)thiophen-3-amine and 2-(4-methoxyphenyl)acetic acid according to protocol B and was purified by HPLC. Method [7] Retention time 5.91 min by HPLC (MH+ 326). 1H NMR (300 MHz, DMSO) δ s (11.02, 1H), 8.81 (d, J=0.9 Hz, 1H), 8.45 (d, J=2.7 Hz, 1H), 8.26 (m, 1H), 7.92 (d, J=5.4 Hz, 1H), 7.74 (d, J=5.4 Hz, 1H), 7.33 (d, 8.7 Hz, 2H), 6.99 (d, J=8.7 Hz, 2H), 3.78 (s, 3H), 3.72 (s, 2H).

Workup

  1. customwas purified by HPLC

Sources & evidence

ORD record
ord-0ed3bd275f594beca75fc6acdd6b3c35
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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