1239464-79-9 → HCID 52948593, compound

Participants

Reaction Steps

The crude 4-(pyrazin-2-yl)thiazol-5-amine was coupled with 2-(isoquinolin-5-yl)acetic acid hydrochloride using procedure A and was purified by HPLC purified to afford desired material as a white trifluoroacetic acid salt (107 mg). Method [8]: rt=3.71 min; 1H NMR (CDCl3) δ12.16 (s, 1H), 9.80 (s, 1H), 9.48 (d, J=1.2 Hz, 1H), 8.64 (d, J=6.4 Hz, 1H), 8.47 (s, 1H), 8.45 (d, J=2.7 Hz, 1H), 8.39 (d, J=8.5 Hz, 1H), 8.31 (d, J=6.5 Hz, 1H), 8.15 (d, J=7.2 Hz, 1H), 8.10-7.98 (m, 2H), 4.45 (s, 2H); MH+ 348.0.

Provenance & Evidence