HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester → 3-amino-N-cyclopropyl-2-hydroxy-3-methylbutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester | HCID 67385732 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 3-amino-N-cyclopropyl-2-hydroxy-3-methylbutanamide | HCID 57562093 | — |
Reaction Steps
A solution of (2-cyclopropylcarbamoyl-2-hydroxy-1,1-dimethylethyl)-carbamic acid tert-butyl ester in CH2Cl2 (10 mL) and TFA (5 mL) was stirred at room temperature for 4 h. The reaction mixture was then concentrated and chased with toluene to yield 3-amino-N-cyclopropyl-2-hydroxy-3-methylbutyramide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450373B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-7a267b3c06ef4c20be9e6c6148a4b2e0 |
| Source note | uspto-grants-2013_05 |