HCID 67387379, compound → HCID 67387004, compound

Participants

Reaction Steps

3-Nitro-3′-trifluoromethoxy-biphenyl-4-ylamine (28.5 g) was dissolved in methanol (250 mL). To this solution, Pd—C (10%, Degussa Type, 15 g) was added, and the resulting mixture was stirred under a hydrogen atmosphere for 4 hours. The solution was filtered on celite, washed with methanol, and then concentrated to give 3′-trifluoromethoxy-biphenyl-3,4-diamine (17.8 g) which was used without further purification. 3′-Trifluoromethoxy-biphenyl-3,4-diamine (17.8 g) was taken up into methanol (100 mL), and cyanogen bromide (8.9 g) was added. The resulting mixture was stirred at room temperature for about 30 minutes. The solution was concentrated to dryness. The resulting crude product was triturated with diethyl ether (100 mL), filtered and dried to obtain 5-(3-trifluoromethoxy-phenyl)-1H-benzoimidazol-2-ylamine hydrobromide salt (21.3 g), which was used without further purification. LCMS (m/z): 293.9.

Provenance & Evidence