2-(Oxan-2-yloxy)ethan-1-ol → HCID 178522478, compound

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Reaction Steps

6-(2-Hydroxy-ethoxy)-imidazo[1,2-b]pyridazine-2-carboxylic acid [5-(3-chloro-phenyl)-1H-benzoimidazol-2-yl]-amide (41 mg) was prepared from 6-chloro-imidazo[1,2-b]pyridazine-2-carboxylic acid [5-(3-chloro-phenyl)-1H-benzoimidazol-2-yl]-amide (80 mg) and 2-(tetrahydro-pyran-2-yloxy)-ethanol as described in Example 122. LCMS (m/z): 449.7. 1H NMR (400 MHz, DMSO-d6): δ 12.38 and 11.4 (1H, s) 8.84 (1H, s) 8.15 (1H, d) 7.78 1H, s) 7.71 (1 h, s) 7.56-7.66 (2H, m) 7.45-7.51 (2H, m) 7.39 (1H, d) 7.07 (1H, d) 4.98 (1H, t) 4.38 (2H, t) 3.79 (2H, q).

Provenance & Evidence