Lithium Hydroxide → HCID 86649837, compound

Participants

Reaction Steps

(2-{2-[2-(2-t-Butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid ethyl ester (Compound 5, 12.2 g, 0.026 mol) was dissolved in tetrahydrofuran (THF, 150 mL) and then stirred. After slowly adding 2 N lithium hydroxide (LiOH) aqueous solution (40 mL), the mixture was stirred at room temperature for 40 minutes. After removing THF from the reaction mixture, 1 N HCl was slowly added for acidification. After extracting 3 times with dichloromethane, the organic layer was separated, dried with magnesium sulfate, and then concentrated. The target compound (2-{2-[2-(2-t-butoxycarbonylaminoethoxy)ethoxycarbonylamino]ethoxy}ethoxycarbonylamino)acetic acid (Compound 7, 11 g, 90.1%) was yielded.

Provenance & Evidence