Lithium Hydroxide → HCID 86649840, compound

Participants

Reaction Steps

Ethyl 54,54-dimethyl-4,12,20,28,36,44,52-heptaoxo-5,8,13,16,21,24,29,32,37,40,45,48,53-tridecaoxa-3,11,19,27,35,43,51-heptaazapentapentacontan-1-oate (Compound 13, 2.4 g, 0.0025 mol) was dissolved in THF (30 mL) and then stirred. After slowly adding 2 N lithium hydroxide aqueous solution (8 mL), the mixture was stirred at room temperature for 40 minutes. After removing THF from the reaction mixture, 1 N HCl aqueous solution was slowly added for acidification. After extracting 3 times with dichloromethane, the organic layer was separated, dried with magnesium sulfate, and then concentrated. The target compound 54,54-dimethyl-4,12,20,28,36,44,52-heptaoxo-5,8,13,16,21,24,29,32,37,40,45,48,53-tridecaoxa-3,11,19,27,35,43,51-heptaaza-1-pentapentacontanoic acid (Compound 14, 2.3 g, 99.1%) was yielded.

Provenance & Evidence