反应详情

Jones reagent (˜60 mL) was added dropwise to a stirring solution of Methyl 3-(benzyloxy)-5-(4-formylphenoxy)benzoate (Intermediate 12) (30 g, 82.9 mmol, 1 equiv.) in acetone (200 mL) at room temperature until a brown color persists. The reaction mixture was diluted with water and extracted several times with dichloromethane. The combined organic extracts was washed with brine, dried over anhydrous sodium sulphate, filtered and concentrated to furnish acid as white solid (30 g).

1. extractionextracted several times with dichloromethane
2. washThe combined organic extracts was washed with brine
3. dry with materialdried over anhydrous sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated