HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(3-(4-fluorophenoxy)phenyl)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Reactant | N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide | HCID 67036908 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(3-(4-fluorophenoxy)phenyl)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide | HCID 57920193 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
To a solution of N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide from example 1, step B, (20 mg, 0.05 mmol) in isopropanol (1 mL), was added 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (15 mg, 0.1 mmol) and triethylamine (0.04 mL, 0.3 mmol). The reaction mixture was heated at 180° C. for 30 minutes under microwave conditions, and then concentrated under vacuum. The product was isolated by prep HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450332B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-18951792e8de4472997aea2ef4478b56 |
| Source note | uspto-grants-2013_05 |