HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 5-Nitro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2,3-Dihydro-1-benzofuran-7-carboxylic acid | HCID 2795014 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-Nitro-2,3-dihydrobenzo[b]furan-7-carboxylic acid | HCID 14838655 | — |
Reaction Steps
Nitric acid (9 ml) was added to a cooled (ice bath) solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (5.1 g, 31 mmol) in trifluoroacetic acid (45 ml). After 4 hours the mixture was quenched into ice-water (150 ml) and the mixture filtered to give 5-nitro-2,3-dihydrobenzo[b]furan-7-carboxylic acid, which was washed with water and used crude (wet) in the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450506B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c2952578a3d7421c9d062420f5bfdacd |
| Source note | uspto-grants-2013_05 |