Benzylamine → Benzyl(2,2-difluoroethyl)amine

Participants

Reaction Steps

An amount of 757.9 g (7.39 mol) of 2,2-difluoro-1-chloroethane and 800 g of benzylamine (7.39 mol) are heated in an autoclave at an internal temperature of 120° C. for 16 hours. Subsequently, 1400 g of water are added and the aqueous phase is separated. The organic phase is distilled at standard pressure and the excess 2,2-difluoro-1-chlorethan is distilled off Remaining traces of 2,2-difluoro-1-chloroethane are distilled off under vacuum (200 mbar). An amount of 587 g of N-benzyl-2,2-difluoroethanamine is obtained as residue with a purity of 97.4%. This corresponds to a yield of 93.4%, based on reacted benzylamine. The benzylamine hydrochloride in the aqueous phase can be rereleased by addition of sodium hydroxide solution and be used once again. A further 21 g of N-benzyl-2,2-difluoroethanamine are present in the aqueous phase so that the yield is increased to 96%.

Provenance & Evidence