HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenylboronic acid → (R)-2,2,2-Trifluoro-1-(3'-fluorobiphenyl-4-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | (1R)-1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-ol | HCID 12640349 | — |
| Product | (R)-2,2,2-Trifluoro-1-(3'-fluorobiphenyl-4-yl)ethanol | HCID 59597036 | — |
Reaction Steps
Similar to the above procedure, the title compound was prepared from (R)-1-(4-bromophenyl)-2,2,2-trifluoroethanol (2) and 3-fluorophenylboronic acid. 1H NMR (CDCl3): δ 7.62 (d, J=6.0 Hz, 2H), 7.56 (d, J=6.3 Hz, 2H), 7.42 (m, 2H), 7.28 (m, 1H), 7.06 (m, 1H), 5.82 (q, J=5.1 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450532B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-88e804f48d5e44439ed95e76192004f4 |
| Source note | uspto-grants-2013_05 |