Sodium Carbonate → HCID 58286559, compound

Participants

Reaction Steps

A solution of 1,1-Dimethylethyl (1S,4S)-5-(1H-benzimidazol-2-ylcarbonyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (20 g, 58.5 mmol) in 200 ml TFA/DCM (20%) was stirred at room temperature for 1 h. The reaction mixture was basified by addition of sat. aqueous Na2CO3 and then extracted with DCM (4×200 mL). The DCM solution was dried over anhydrous Na2SO4 and concentrated to give the title compound (6.5 g) as a pale yellow solid. LCMS (m/z): 243.1 (M+H).

Provenance & Evidence