HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl alcohol → Tert-butyl 3-hydroxy-3-(3-(3-hydroxyprop-1-ynyl)phenyl)propylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl alcohol | HCID 7859 | — |
| Reactant | Tert-butyl 3-(3-bromophenyl)-3-hydroxypropylcarbamate | HCID 57608439 | — |
| Product | Tert-butyl 3-hydroxy-3-(3-(3-hydroxyprop-1-ynyl)phenyl)propylcarbamate | HCID 66743507 | — |
Reaction Steps
Sonogashira reaction of bromide 39 with propargyl alcohol gave tert-butyl 3-hydroxy-3-(3-(3-hydroxyprop-1-ynyl)phenyl)propylcarbamate as brown oil. Yield (0.880 g, 94%): 1H NMR (400 MHz,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450527B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-a24ca8c054a646bba2ea0d8785e15211 |
| Source note | uspto-grants-2013_05 |