HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-(5-Bromo-2-methylphenyl)-3-hydroxypropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 5-Bromo-2-methylbenzaldehyde | HCID 10420289 | — |
| Product | 3-(5-Bromo-2-methylphenyl)-3-hydroxypropanenitrile | HCID 66629245 | — |
Reaction Steps
Addition of 5-bromo-2-methylbenzaldehyde to acetonitrile gave 3-(5-bromo-2-methylphenyl)-3-hydroxypropanenitrile as a pale yellow oil. Yield (3.33 g, 86%): 1H NMR (400 MHz, DMSO-d6) δ 7.61 (d, J=2.0 Hz, 1H), 7.35 (dd, J=8.0, 2.0 Hz, 1H), 7.09 (d, J=8.0 Hz, 1H), 5.96 (d, J=4.4 Hz, 1H), 5.04-5.00 (m, 1H), 2.88 (ABd, J=16.8, 4.4 Hz, 1H), 2.77 (ABd, J=16.8, 6.4 Hz, 1H), 2.23 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450527B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-019db1e6b616494b938ecd73cca03f31 |
| Source note | uspto-grants-2013_05 |