4-Ethynylheptan-4-ol → HCID 57956724, compound

HRID 2098549Notes

Reaction equation

HRID 2098549 reaction equation
[C:1]([C:3]([OH:10])([CH2:7][CH2:8][CH3:9])[CH2:4][CH2:5][CH3:6])#[CH:2].Br[C:12]1[CH:13]=[C:14]([CH:18]([OH:22])[CH2:19][C:20]#[N:21])[CH:15]=[CH:16][CH:17]=1>>[OH:22][CH:18]([C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([C:2]#[C:1][C:3]([OH:10])([CH2:7][CH2:8][CH3:9])[CH2:4][CH2:5][CH3:6])[CH:13]=1)[CH2:19][C:20]#[N:21]

Participants

3

Reactant 2

HCID 123838984-Ethynylheptan-4-olHCID 576083633-(3-Bromophenyl)-3-hydroxypropanenitrile

Product 1

HCID 57956724HCID 57956724, compound

Procedure

Coupling of 4-ethynylheptan-4-ol with 3-(3-bromophenyl)-3-hydroxypropanenitrile following the method described in Example 12 gives 3-hydroxy-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propanenitrile as a light yellow oil.

Sources & evidence

ORD record
ord-67fba48480a54cbd80dd6c4f75fe324c
Source dataset
uspto-grants-2013_05
Patent number
US08450527B2

Reaction notes

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