N-prop-2-ynylphthalimide → HCID 66750026, compound

HRID 2098558Notes

Reaction equation

HRID 2098558 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][CH2:6][C:7]1([OH:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH2:17]([N:20]1[C:28](=[O:29])[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]1=[O:30])[C:18]#[CH:19]>>[OH:13][C:7]1([CH2:6][CH2:5][C:4]2[CH:3]=[C:2]([C:19]#[C:18][CH2:17][N:20]3[C:28](=[O:29])[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]3=[O:30])[CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 81644N-prop-2-ynylphthalimideHCID 57956767HCID 57956767, compound

Product 1

HCID 66750026HCID 66750026, compound

Procedure

Coupling of 1-(3-bromophenethyl)cyclohexanol with 2-(prop-2-ynyl)isoindoline-1,3-dione following the method described in Example 12 gives 2-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)phenyl)prop-2-ynyl)isoindoline-1,3-dione.

Sources & evidence

ORD record
ord-ed1b646882f747e8843c160deef0cc74
Source dataset
uspto-grants-2013_05
Patent number
US08450527B2

Reaction notes

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