HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 5-(4-[2-(Tert-butyldimethylsilyloxy)ethyl]-1-piperazinylmethyl)-1-(tert-butoxycarbonyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 68490755 | HCID 68490755 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(4-[2-(Tert-butyldimethylsilyloxy)ethyl]-1-piperazinylmethyl)-1-(tert-butoxycarbonyl)indole | HCID 68490861 | 90% |
Reaction Steps
In a similar manner to Step 1 of Reference Example 18, 5-[4-(2-hydroxyethyl)-1-piperazinylmethyl]-1-(tert-butoxycarbonyl)indole (5.02 g, 14.0 mmol) was dissolved in DMF (50 mL), and the solution was treated with imidazole (1.43 g, 21.0 mmol) and tert-butyldimethylsilyl chloride (3.16 g, 21.0 mmol) to obtain 5-(4-[2-(tert-butyldimethylsilyloxy)ethyl]-1-piperazinylmethyl)-1-(tert-butoxycarbonyl)indole (5.97 g, yield 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d9f5bf04589944f49b120415ff708821 |
| Source note | uspto-grants-2010_06 |