3,3-Dimethylbutanoyl chloride → N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-3,3-dimethylbutanamide

HRID 2098671Notes

Reaction equation

HRID 2098671 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH2:11])=[CH:8][C:6]=2[N:7]=1.[C:18]([CH2:22][C:23](Cl)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][C:9]([NH:11][C:23](=[O:24])[CH2:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 815143,3-Dimethylbutanoyl chlorideHCID 595928682-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine

Product 1

HCID 86618392N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-3,3-dimethylbutanamide

Procedure

2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-amine (40 mg) was reacted with 41 μL of tert-butylacetyl chloride via General Procedure G to give N-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-3,3-dimethylbutanamide.

Sources & evidence

ORD record
ord-03b0ae67c4174f7b98b38a3b955473d0
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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