Formaldehyde → HCID 86618400, compound

Participants

Reaction Steps

To 2-chloro-6-(4-methoxy-piperidin-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (175 mg) in methanol (3 ml) was added formaldehyde (37% solution in water, 0.11 ml) and sodium borohydride (54 mg). The reaction mixture was stirred at room temperature overnight. Chloroform/brine extraction and purification on silica gave 2-chloro-4-yl)-6-(4-methoxy-1-methyl-piperidin-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.

Provenance & Evidence