4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole → N-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylsulfonyl-1-methylpyrrolidin-3-amine

Participants

Reaction Steps

N-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-N-(1-methyl-pyrrolidin-3-yl)-methanesulfonamide was reacted with 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole in General Procedure A to yield 195. NMR: (CDCl3): 1.96 (1H,m); 2.19 (2H,m); 2.33 (4H,m); 2.48 (1H,m); 2.90 (5H,m); 3.94 (4H,m); 4.10 (4H,m); 4.57 (1H,m); 4.90 (2H,s); 7.50 (1H,s); 7.53 (1H,d,J=7.4Hz); 7.10 (1H,d,J=8.2Hz); 8.30 (1H,d,J=7.1Hz); 9.03 (1H,s); 10.14 (1H, br s). MS: (ESI+): MH+=528

Provenance & Evidence