HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole → 2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-ylamino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole | HCID 45480186 | — |
| Reactant | 2-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-ylamino)ethanol | HCID 86618411 | — |
| Product | 2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-ylamino)ethanol | HCID 59592891 | — |
Reaction Steps
2-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-ylamino)ethanol (28 mg) was coupled to 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 via General Procedure A. The product was purified by reverse phase HPLC to yield 21 mg of 226. MS (Q1) 397 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-6ed2e54375604274adf01c4d9aa05924 |
| Source note | uspto-grants-2013_05 |