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Isoamyl Nitrite → 2-(1H-indazol-6-yl)-4-morpholinothieno[3,2-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isoamyl Nitrite | HCID 8053 | — |
| 反応物 | 2-Methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)-phenylamine | HCID 67188949 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-(1H-indazol-6-yl)-4-morpholinothieno[3,2-d]pyrimidine | HCID 25023744 | — |
反応手順
To a solution of 2-methyl-5-(4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl)-phenylamine (99 mg) in chloroform (10 mL) and acetic acid (2 mL) was added isoamyl nitrite (44 μL). The reaction mixture was stirred for 2 days at room temperature. The mixture was then quenched with sodium bicarbonate solution and extracted in to chloroform and reduced in vacuo. The residue was purified using flash chromatography to yield 229. MS: ESI MH+ 338
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08450315B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-7612dd26b14a4bc7a35bcbf943d46688 |
| 出典メモ | uspto-grants-2013_05 |