3-Aminophenol → HCID 59592864, compound

HRID 2098726Notes

Reaction equation

HRID 2098726 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[N:11]=[C:12]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)[C:13]4[S:18][C:17]([C:19](O)=[O:20])=[CH:16][C:14]=4[N:15]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[OH:28][C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH2:32]>>[OH:28][C:29]1[CH:30]=[C:31]([NH:32][C:19]([C:17]2[S:18][C:13]3[C:12]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[N:11][C:10]([C:5]4[CH:6]=[CH:7][CH:8]=[C:9]5[C:4]=4[CH:3]=[N:2][NH:1]5)=[N:15][C:14]=3[CH:16]=2)=[O:20])[CH:33]=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 595931412-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

Product 1

HCID 59592864HCID 59592864, compound

Procedure

2-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid 13 (30 mg) was coupled to 3-hydroxyaniline via General Procedure B. The product was purified via reverse phase HPLC to give 7.7 mg of 246. MS (Q1) 472.7 (M)+

Workup

  1. customThe product was purified via reverse phase HPLC

Sources & evidence

ORD record
ord-20db36423a58400baf253e400c2646fc
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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