HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N,N-dimethylacetamide → N-((dimethylcarbamoyl)methyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N,N-dimethylacetamide | HCID 4961823 | — |
| Reactant | 2-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid | HCID 59593141 | — |
| Product | N-((dimethylcarbamoyl)methyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide | HCID 59593109 | — |
Reaction Steps
30 mg of 2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid 13 was coupled to 2-amino-N,N-dimethylacetamide via General Procedure B. The product was purified via reverse phase HPLC to give 6.5 mg of 248. MS (Q1) 465.8 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-fdc5bcbe2de04414ab097a995db57e1b |
| Source note | uspto-grants-2013_05 |