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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2098745Generated: October 31, 2026

1-Acetylpiperazine → (2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)(4-acetylpiperazin-1-yl)methanone

https://huagongshe.com/reaction/2098745

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-AcetylpiperazineHCID 83795—
Reactant2-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acidHCID 59593141—
Product(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)(4-acetylpiperazin-1-yl)methanoneHCID 59593152—

Reaction Steps

30 mg of 2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid 13 was coupled to 1-acetylpiperazine via General Procedure B. The product was purified via reverse phase HPLC to give 16.8 mg of 267. MS (Q1) 491.8 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08450315B2
Source datasetuspto-grants-2013_05
ORD IDord-c69788c10c09400cb522da000bc44795
Source noteuspto-grants-2013_05