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Nicotinoyl chloride → N-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nicotinoyl chloride | HCID 82604 | — |
| 反応物 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole | HCID 45480186 | — |
| 反応物 | (2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine | HCID 46180727 | — |
| 生成物 | N-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)nicotinamide | HCID 59592942 | — |
反応手順
(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine 27 was acylated with nicotinoyl chloride following General Procedure K and then reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 (34 mg) following General Procedure A to give 288. MS (Q1) 472 (M)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08450315B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-1ec3954077194ab98d24b0afea537c97 |
| 出典メモ | uspto-grants-2013_05 |