4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole → HCID 59592838, compound

HRID 2098759Notes

Reaction equation

HRID 2098759 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]2[O:10][C:9]([C:11]([NH2:13])=[O:12])=[CH:8][C:6]=2[N:7]=1.CC1(C)C(C)(C)OB([C:28]2[CH:36]=[CH:35][CH:34]=[C:33]3[C:29]=2[CH:30]=[N:31][NH:32]3)O1>>[NH:32]1[C:33]2[C:29](=[C:28]([C:2]3[N:3]=[C:4]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)[C:5]4[O:10][C:9]([C:11]([NH2:13])=[O:12])=[CH:8][C:6]=4[N:7]=3)[CH:36]=[CH:35][CH:34]=2)[CH:30]=[N:31]1

Participants

3

Reactant 2

HCID 454801864-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazoleHCID 86618417HCID 86618417, compound

Product 1

HCID 59592838HCID 59592838, compound

Procedure

2-Chloro-4-morpholinofuro[3,2-d]pyrimidine-6-carboxamide was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 via General Procedure A to give, after purification by reverse HPLC, 291. MS (Q1) 365 (M+)

Workup

  1. customto give
  2. customafter purification by reverse HPLC, 291

Sources & evidence

ORD record
ord-2b8b38e06c834383bc3524c98103bedc
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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