HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 1-(2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | 2-Chloro-4-(morpholin-4-yl)thieno(2,3-d)pyrimidine | HCID 13038189 | — |
| Product | 1-(2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)ethanol | HCID 86618421 | — |
Reaction Steps
2-chloro-4-morpholinothieno[2,3-d]pyrimidine (300 mg) was reacted with acetaldehyde via General Procedure D to give 1-(2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)ethanol. This crude intermediate was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-indazole 7 via General Procedure A to yield 100.2 mg of 308 following reverse phase HPLC purification. MS (Q1) 382.1 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-a0990d8fef3e4ed5ae5d0d98485b6121 |
| Source note | uspto-grants-2013_05 |