HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxyphenylacetyl chloride → HCID 59593012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxyphenylacetyl chloride | HCID 2734688 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole | HCID 45480186 | — |
| Reactant | (2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine | HCID 46180727 | — |
| Product | HCID 59593012 | HCID 59593012 | 42% |
Reaction Steps
(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanamine 27 from Example 11 (53.2 mg, 0.19 mM) was reacted with 4-methoxyphenylacetyl chloride (2.2 eq) followed by Suzuki coupling of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-indazole 7 as per General Procedure K. Complete reaction was confirmed by LCMS and the reaction was concentrated in vacuo to give 18.8 mg of 378 after RP-HPLC purification (42% yield). MS (Q1) 515.3 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-f26862e1a40e4b1d919c92845c6e13bd |
| Source note | uspto-grants-2013_05 |