Methanol → HCID 12751901, compound

HRID 2098831Notes

Reaction equation

HRID 2098831 reaction equation
CS[CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]O>O>[CH3:22][S:18]([CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15])(=[O:20])=[O:17]

Participants

5

Reactant 3

HCID 887MethanolHCID 12751899HCID 12751899, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 12751901HCID 12751901, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 2-(2-methylsulfanyl-ethyl)-isoindole-1,3-dione (400 mg) in methanol (10 mL) was added a solution of oxone (1.67 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(2-methanesulfonyl-ethyl)-isoindole-1,3-dione as a white solid.

Workup

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-f1450827d8214106bf332d69d428a1b8
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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