Methanol → HCID 13459059, compound

HRID 2098835Notes

Reaction equation

HRID 2098835 reaction equation
CS[CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].O[O:18][S:19]([O-:21])=O.[K+].[CH3:23]O>O>[CH3:23][S:19]([CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])(=[O:21])=[O:18]

Participants

5

Reactant 3

HCID 887MethanolHCID 134589972-[3-(Methylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dioneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 13459059HCID 13459059, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 2-(3-methylsulfanyl-propyl)-isoindole-1,3-dione (440 mg) in methanol (10 mL) was added a solution of oxone (1.73 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(3-methanesulfonyl-propyl)-isoindole-1,3-dione as a white solid.

Workup

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-fcc3c765e5f24ac3bc235062975207a9
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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