HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 59592939, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 5-Indolylboronic acid | HCID 2734361 | — |
| Reactant | 1-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine | HCID 59592937 | — |
| Product | HCID 59592939 | HCID 59592939 | 44% |
Reaction Steps
1-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine 55 from Example 11a was reacted with acetyl chloride (1.2 eq) followed by Suzuki coupling of indole-5-boronic acid as per General Procedure K. Complete reaction was confirmed by LCMS and the reaction was concentrated in vacuo to give 33.1 mg of 392 after RP-HPLC purification (44% yield). MS (Q1) 422.2 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450315B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-778189ce70144514806979e5cfd4ea93 |
| Source note | uspto-grants-2013_05 |