HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2098879Generated: November 1, 2026
Thiourea → 4-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)thiazol-2-amine
https://huagongshe.com/reaction/2098879
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-Bromo-1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)ethanone | HCID 59592905 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)thiazol-2-amine | HCID 59592971 | — |
Reaction Steps
To a solution of 2-bromo-1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)ethanone (1.0 eq) dissolved in EtOH was added thiourea. Reaction mixture was heated at 70° C. until completed, then extracted in dichloromethane with saturated bicarbonate solution one time. The organic layer is dried, filtered and concentrated to yield the crude intermediate. This intermediate is purified by flash chromatography to yield 4-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)thiazol-2-amine. MS (Q1) 413 (M+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08450315B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-dc9e3e1ba69c47f48caf7a02b7dfc8ca |
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| Source note | uspto-grants-2013_05 |
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