HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 57705690, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | [1,1′-Biphenyl]-4-carboxylic acid, 2-(6,6-dimethyl-1-cyclohexen-1-yl)-2′-fluoro-5′-methoxy-, methyl ester | HCID 57706936 | — |
| Product | HCID 57705690 | HCID 57705690 | 90.2% |
Reaction Steps
To a stirred solution of T14.3 (0.300 g, 0.814 mmol) in THF (0.0587 g, 0.814 mmol) at 0° C. was added LAH in THF (1.63 mL, 1.63 mmol, 1.0M). The reaction was stirred for 4.5 hours and then 1N NaOH(aq) was added to quench the mixture. The reaction was extracted three times with EtOAc. After drying over anhydrous magnesium sulfate and filtering, the organic solvent was removed under reduced pressure and the product was then purified on silica gel (0-20% EtOAc in hexanes) to yield T14.4 as a colorless oil (0.250 g, 90.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08450522B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-24fca0e05c704bb38841d46e487b87a2 |
| Source note | uspto-grants-2013_05 |