Hydrochloric Acid → HCID 59590827, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 38.3 (190 mg, 0.78 mmol) and potassium hydroxide (860 mg, 15 mmol) in water (0.5 mL) and ethylene glycol (1.0 mL) was heated in a sealed tube and stirred at 133° C. overnight. The reaction was cooled and then acidified with hydrochloric acid to pH ˜1. The mixture was extracted with EtOAc (5×), and the combined organic layers were dried over magnesium sulfate. The filtrate was concentrated to yield crude 38.4 and taken directly to the next step. MS ESI (neg.) m/e: 237.1 (M−H)−.

Provenance & Evidence